Apr 25, 2001
Dr Boyle thank you for your great work on this site.A lot of people I know have reduced the dose of their meds due to side effects mostly the PI's without telling their Doctors,but the thing is that they are remaining undectable and have all been doing this for years.My question is this has any studies been done with a reduced dosing too see weather its effective in both controlling the virus and lessening side effects caused by these drugs.And i know a lot of guys who do this,I personally don't but its interesting that they are still not developed resistence on the reduced doses.What do you think,thank you.
Response from Dr. Boyle
Reducing doses without consulting a doctor is very dangerous and may affect the durability of the antiretroviral regimen. The antiretroviral doses prescribed are those that lead to adequate blood levels and viral suppression. If a dose lower than that is taken, those levels may not be adequate and low levels of viral replication may eventually cause the regimen to fail. Anyone who is having problems with side effects should discuss these with their doctor, who can consider a dose adjustment (if that's appropriate based on the patient's weight), prescribe medications to help alleviate or eliminate the side effects, or recomend an antiretroviral change. The bottom line is that all of the studies and data support the doses commonly prescribed, and not taking the medications as directed is a recipe for disaster.
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