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Lipids
May 3, 2009

Are people who are on Isentress seeing raised lipids?

Thanks, W.

Response from Dr. McGowan

Dear W.

Thanks for your post.

Although the data are not as deep as for some of our older treatments, the initial studies seem to show that Isentress (raltegravir, an HIV integrase inhibitor) is fairly lipid neutral. This has been seen in studies of people starting treatment for the first time (naives, Startmrk trial) and in switching from Protease inhibitors (Switchmrk trial). One caveat about the switch study was that after changing from a boosted PI to raltegravir, some people saw an increase in their viral load, so all such switches need to be done very carefully to be sure that the new combo has at least 3 active drugs in it.

Best, Joe



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