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Apr 2, 2009

I am a 33yr old male i was diagnose with hiv/aids virus about a year ago. My viral load at that time was 686,000 and cd4 was 186 at this present time viral load is undetectable and the cd4 is aroud 369. The reyataz is causeing my eyes to be yellow sometimes so i was wondering is ther another medication that i could take. I have not been haveing any yellowing of my skin at all my meds are 2 reyataz 150mg 1 truvada and 1 norvir. And are these drugs killing my liver.

Response from Dr. Young

Hello and thanks for your post.

First, it sounds like your medications are working very well on your virus and CD4 count.

Elevations in bilirubin are not uncommon among persons who receive Norvir-boosted atazanavir (Reyataz). While not medically serious or an indicator of liver failure, this elevation can cause yellowing of the skin (jaundice) or eyes (icterus), as you're experiencing.

Since many of our patients would rather not experience this side effect, we will often start our patients on alternative ritonavir boosted PIs, usually fosamprenavir (Lexiva) or darunavir (Prezista). In your case, switching from atazanavir to either of these PIs would almost certainly improve your symptoms and not incur any risk of treatment failure.

I'd talk to your doctor about your concerns. Let us know how things turn out.


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