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CHANGING DRUMS Feb 26, 2009 I have been taking sustiva+ Lamividine+ zidovidine for 1 year now and I have not had any problemsgl. I'm planning to conceive soon, and I know Sustiva is not good while pregnant. Which combination is best for me during this time. Please adive me. |
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| Response from Dr. Young
 Hello and thanks for your post. Efavirenz (Sustiva, Stocrin) is usually not recommended during pregnancy, especially during the first trimester- because of risk of certain birth defects. We'll try to switch female patients planning pregnancy (or during first trimester) from efavirenz to a boosted protease inhibitor- usually lopinavir/ritonavir (Kaletra). AZT+3TC (Combivir) is usually recommended during pregnancy; since you're already taking this, no switch would be needed. Hence, a preferred pregnancy regimen is AZT+3TC + lopinavir/ritonavir. Note that during third trimester, the levels of the protease inhibitor typically drop (as body weight increases), requiring an increase in dose. I hope this helps. BY | ||||||||
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