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Lymphoma and HIV
Nov 28, 2008

I was wondering if there is any data or information available to the claim that HIV meds can cause lymphoma?

Response from Dr. DeJesus

There are some early data in the development of some of the newest HIV medications that have suggested some association of some HIV medications with an increased incidence of some tumors (malignancies, cancers), not necessarily lymphomas. But, upon more careful review of the data, and continue follow up of patients on treatment on those medications, this association between cancer and HIV meds have now been cleared for the most part.

More specifically, these initial associations occurred with the use of raltegravir , an integrase inhibitor, and CCR5 entry inhibitors (maraviroc and vicriviroc). For raltegravir, subsequent data, clearly demonstrated that the initial association did not sustain, thus the drug is currently considered at no increased risk for malignancies. For the CCR5 entry inhibitors, the subsequent data collected appears to suggest no association, but many patients on these agents are continued to be followed to assess longer term safety.

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