Question about HAART
Nov 28, 2008
If I understand correct, we must take at least two kind of ARV-s - for example 1 PI & 1 NRTI. Then why do we have to take 3 medicines and both of them are the same kind - 2 sorts of NRTI. F.ex. Kaletra + Truvada but not only Kaletra + Viread?Thanks for the time you spend for us!
Response from Dr. Young
Hello and thank you for your comments and question.
All current US- and international treatment guidelines recommend the use of three (or four) drug regimens. This is because in earlier, less-enlightened times, two drug therapies were used- often associated with high rates of treatment failure. Indeed, even today, regimens that spare nucleosides (NRTIs) have failed to demonstrate any significant advantages, even some disadvantages. This shouldn't be interpreted to say that we will always use three drug regimens; there are data on single drug regimens with boosted protease inhibitors that suggest that the dogma need not always apply.
Nevertheless, when it comes to first-line treatments, the time has come not to use unproven strategies (outside of clinical studies)- rather to stick to regimens (three drug as they are), that have been shown to be generally very safe, very effective and to reduce the suffering and death from AIDS.
Thanks for reading.
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