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Med Switch?
Oct 1, 2008

I swiched from Kaletra to the new protease inhibitor Prezista. My doctor scheduled me to take 3 300mg pills with one 100mg Norvir with my Truvada. Is this the correct dosing schedule I know they are investigating one 800mg Prezista right now in clincal trials. Is my schedule ok? Thanks for your input

Response from Dr. Young

Thanks for your post.

There is a lot of interest in the newest PI, darunavir (Prezista). While currently FDA-approved for twice daily use in treatment experienced patients, the ARTEMIS clinical trial has shown very promising results with a 800 mg (with 100 mg ritonavir), once-daily dose for first-line treatment.

This is undoubtedly the basis of your healthcare provider's selection of your medications. Since a 800 mg dose is not available currently, many doctors are substituting 3- 300 mg pills to yield a 900 mg+ 100 mg ritonavir regimen. The 400 mg pill (and FDA approval for the dosing) should occur before year's end.

Let us know how things turn out.

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