Oct 1, 2008
I swiched from Kaletra to the new protease inhibitor Prezista. My doctor scheduled me to take 3 300mg pills with one 100mg Norvir with my Truvada. Is this the correct dosing schedule I know they are investigating one 800mg Prezista right now in clincal trials. Is my schedule ok? Thanks for your input
Response from Dr. Young
Thanks for your post.
There is a lot of interest in the newest PI, darunavir (Prezista). While currently FDA-approved for twice daily use in treatment experienced patients, the ARTEMIS clinical trial has shown very promising results with a 800 mg (with 100 mg ritonavir), once-daily dose for first-line treatment.
This is undoubtedly the basis of your healthcare provider's selection of your medications. Since a 800 mg dose is not available currently, many doctors are substituting 3- 300 mg pills to yield a 900 mg+ 100 mg ritonavir regimen. The 400 mg pill (and FDA approval for the dosing) should occur before year's end.
Let us know how things turn out.
Is my partner being dosed correctly?
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