is this combo good?
Jun 22, 2008
hi there can you tell me if this combo is good PREZISTA(DARUNAVIR)+NORVIR?twice daily ?im resistant to sustiva group..
Response from Dr. Young
Thanks for your post.
I'm wondering if you're referring to a first-line treatment.
For those who have acquired NNRTI ("efavirenz group") resistance, using a ritonavir-boosted PI is definitely recommend for part of a treatment regimen (though not to be used alone). Darunavir is a very potent PI that is currently approved (and recommended) for patients with drug resistant virus, but not yet commonly used in first-line regimens. That said, the medication is very well tolerated and is finding some use in these patients.
We'd typically start with more well studied first-line PIs, such as fosamprenavir (Lexiva, Telzir) or atazanavir (Reyataz), in combination with either Truvada or Epzicom-- these offer well tolerated options that are endorsed by current treatment guidelines.
I hope this helps,
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