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Apr 15, 2008

Hi Doc,

I was in the sexual act when the condom burst. I was with a professional and her HIV status is unknown to me. This happened on 13th Apr 2008. I visited the hospital the next day (14th Apr) when the doc there gave me Duovir-N and asked me to take 2 pills daily for 4 weeks.

The composition is lamivudine ip - 150mg zidovudine ip - 300mg nevirapine ip - 200mg

Can you pls advice if I should continue with the regimen? I hear nevirapine is not a prescribed drug.

Thank you in advance.

Response from Dr. Young

Thanks for your post.

Nevirapine is not recommended for post-exposure prophylaxis (PEP) because of significantly increased risk of liver toxicity. There have been several reports of liver failure on such treatments; AIDSmap has a nice review of this topic.

I would not continue with the regimen, rather continue with two drug therapy with zidovudine+lamivudine. No matter what, speak to your doctor about the situation.


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