Advertisement
The Body: The Complete HIV/AIDS Resource
Follow Us Follow Us on Facebook Follow Us on Twitter Download Our App
Professionals >> Visit The Body PROThe Body en Espanol
   
Ask the Experts About

Choosing Your MedsChoosing Your Meds
           
Rollover images to visit our other forums!
Recent AnswersAsk a Question
  
  • Email Email
  • Glossary Glossary


Viramune and Reyataz questions
Apr 6, 2008

(1) Viramune (nevirapine) is listed as "alternative" regimen in the recently released DHHS guidelines (B2). Is this "simply because of the potential for hepatoxicity and the need for close monitoring for the first 18 weeks, OR is it because of nevirapine's lower efficacy/potency? (the 2NN study seems to indicate that nevirapine is as effective as efaivirenz, Sustiva.)

(2) The recent CASTLE study shows the non-inferiority of boosted Reyataz (atazanavir + a little ritonavir) to Kaletra (lopinavir + norvir). So why the A3 and A2 disparity in the strength of the recommendations?

(3) Most people seem to be taking boosted Reyataz with an NRTI backbone. I understand that that's necessary when the dual-NRTI is necessary. But if it's Epzicom (assuming the HLA-B*5701 test is negative), is unboosted Reyataz just as effective? Or are there general reasons for almost always using boosted 'taz?

Thank you very much.

Response from Dr. DeJesus

Loaded question...we could potentially discuss these in chapters, but here are a few quick answers:

1. You are correct, the reason why Viramune is recommended as an alternative regimen rather than a prefer regimen has to do mainly with the potential for toxicity, and not efficacy.

2. Before the results of Castle Study, presented at this year CROI, there were no large, randomized clinical trials comparing boosted atazanavir to another preferred PI regimen in nave patients. The new set of DHHS guidelines were released just a few days before CROI 08, when the Castle data were presented; so these Castle data were not considered in the revision of this last set of guidelines. It is possible that the strength of this recommendation will then change on the next set of revised guidelines later this year.

3. As a rule, boosted PI's are preferred over unboosted PI's due to the higher concentrations achieved by boosted PI's, increasing the IQ or viral inhibitory quotient and thus increasing the efficacy and the likelihood of virologic suppression; as well as decreasing the potential for the development of resistant mutations upon virologic failure. This was originally a theoretical mathematical calculation that have proven to be true in many studies including the original studies comparing Viracept (unboosted PI) to Kaletra, and most recently in a study comparing boosted vs unboosted atazanavir.



Previous
Truvada+Kaletra or Truvada+Viramune
Next
Trouble concentrating.

  
  • Email Email
  • Glossary Glossary

 Get Email Notifications When This Forum Updates or Subscribe With RSS


 
Advertisement



Q&A TERMS OF USE

This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.

Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.

Review our complete terms of use and copyright notice.

Powered by ExpertViewpoint

Advertisement