I'm taking Sustiva and Epzicom. My only risk factor for adult Diabetes is family history. My fasting glucose has gone up from around 85 to 108 in the last 3 years. This coincides with my meds switch. Is either drug known to increase glucose levels? If so, do you have another drug combo suggestion?

I know 108 is borderline pre-diabetic, but I don't want the level to go up much further. Thanks.

It is unlikely Epzicom is doing this. Sustiva is not notorious for worsening glucose tolerance but there are some data that suggest it can in some people. Certainly, your increase in blood sugar may all be explained by the genetic hand you were dealt at birth.

Assuming your combo has done well for you virologically and immunologically, I suggest you get a 2 hour oral glucose tolerance test. It is pretty easy to do and may help clarify how bad your pre-diabetes is. A hemoglobin A1C level would not hurt either.

If you are overweight you should try to loose a few pounds and needless to say cut out he concentrated sweets.

I would be reluctant to change your regimen until all else is done to improve your sugars and then only if there is evidence of worsening. If you did have to switch one option, if you have never been on any other HIV meds, would be to stay on Epzicom and swap the Sustiva for atazanavir not boosted with ritonavir. Unboosted atazanavir has been found to be sugar friendly and in one study just as good as Sustiva in getting the viral load under control in people just starting HIV meds.

DW