Jan 20, 2008
My family member doctor has suggested that he changes his treatment from Truvada, Valtrex, Zerit and Kaletra that is working well with no side effects to Prezista, Novir, truvada and valtrex do you know of any advantage or disadvantage to such a change.
Response from Dr. Young
Thanks for your post.
Without knowing your treatment and drug resistance history, it's difficult to make specific recommendations.
The switch from your current regimen to one of Truvada (tenofovir/FTC) with Norvir-boosted Prezista should continue to be potent and indeed, at least as the Kaletra to Prezista switch is concerned, be better tolerated with lower impact on lipids (cholesterol and triglycerides). The biggest part of the new regimen is the elimination of Zerit (d4T), a drug which hardly ever sees new prescriptions in this country because of excess risk of lipoatrophy, peripheral neuropathy and pancreatitis. The total number of pills and prescriptions remains the same.
I hope this helps, let us know how the new regimen works for you. BY
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