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Isentress in Addition to OBT
Dec 15, 2007

Dr. Young, I have been reading with great interest that there are trials currently enrolling in which Isentress is being added to an already Optimized HAART therapy where the VL < 50. Is this sort of trial typical for a new drug or is Isentress thought to be capable of doing significant damage to the latent hiv reservoir when added to an OBT?

Response from Dr. Young

Thank you for your post.

Raltegravir (Isentress), the first of the HIV integrase inhibitors prevents the establishment of latently infected cells by preventing integration of the HIV genome into the human chromosome.

This mechanism has generated a lot of interest in the notion that it's use might have additional benefit to persons who's circulating virus is suppressed. Such concepts remain highly experimental and have not (yet) been shown to be (1) true and (2) of any benefit.

It should be a very interesting set of studies to watch for. BY



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