Advertisement
The Body: The Complete HIV/AIDS Resource
Follow Us Follow Us on Facebook Follow Us on Twitter Download Our App
Professionals >> Visit The Body PROThe Body en Espanol
Read Now: Expert Opinions on HIV Cure Research
   
Ask the Experts About

Choosing Your MedsChoosing Your Meds
           
Rollover images to visit our other forums!
Recent AnswersAsk a Question
  
  • Email Email
  • Glossary Glossary


How important is undetectable?
Dec 10, 2007

I have been + for 26 months, and have been on Atripla for 19 months. I have never reached "undetectable' My T cells have been over 800 for the last year, but my Viral Load seems to be all over the place. Three month checks have been 400, 1256, 52, 143 and now 410 in that order. I have a very good doctor that has asked if I want to add another Med to bring my VL under 50. Since my T cells are now in the high 800's, how important is bringing the VL under 50? I'm 47 and would prefer to keep all the bullets I can in my gun for future use as needed. Thoughts?

Response from Dr. Pierone

Although the treatment guidelines suggest that we should strive to bring the viral load to undetectable range, there are no controlled studies done to answer this question for your particular situation.

Given the stable and high CD4+ lymphocyte count it seems reasonable to sit tight. There are many patients who continue this regimen in the face of low level viremia and have many years of immunologic stability with flat or even increasing CD4+ lymphocyte counts.

The risk is that the virus may develop more resistance to this regimen over time. It is likely that the replicating virus has a K103N mutation and an M184V, but a resistance test should be performed to document this pattern. So chances are that the virus is already resistant to 2 of the 3 agents you are on.

Since we don't have high level data to guide us in your situation, my preference is to sit tight and stay with the same regimen for patients of mine with the same issue. It would not be wrong to add a 4th drug or revamp the regimen on the basis of a resistance test, but it may not be necessary.

Good luck!



Previous
First line Isentress in Induction - Maintenance?
Next
cosmetic removal of skin stains caused by ks

  
  • Email Email
  • Glossary Glossary

 Get Email Notifications When This Forum Updates or Subscribe With RSS


 
Advertisement



Q&A TERMS OF USE

This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.

Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.

Review our complete terms of use and copyright notice.

Powered by ExpertViewpoint

Advertisement