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starting medicine
Dec 8, 2007

I am going to be starting meds which is better viramene or kaletra and epizocom.

Response from Dr. Wohl

Better at what? Both Viramune and Kaletra are potent HIV meds and they are both twice a day. The drugs have not been compared head-to-head but Kaletra and Sustiva (Stocrin) have and we know that Sustiva was better at getting the viral load below 50 copies/mL but Kaletra produced modestly higher CD4 cell count increases. Both were well tolerated. Resistance to Viramune and Sustiva is easier to develop compared to Kaletra if adherence is not optimal.

In the US, most HIV doctors would favor Kaletra over Viramune, given the lack of recent data with Viramune. Not also that Viramune is not a good option for those with higher CD4 cell counts due to increased risk of liver and skin adverse effects. The selection between Kaletra and Sustiva is more difficult given the results of the study mentioned above and differences in formulations and toxicities.

For Epzicom, it is now recommended that tests be done to make certain you are not at risk for a hypersensitivity reaction.

DW



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