Could you possibly give a comparison of the best PIs and how does one choose the best for me

This is too huge a topic to answer in a single post. There are merits and disadvantages of each of the protease inhibitors. I think it is first important for you to decide what is most significant for you when choosing meds. Is it pill size, pill number, frequency of dosing, cost? Side effects are important to everyone but which ones are most worrisome to you or less likely to be tolerated? Think of this when discussing the selection of therapy with your doc.

Generally, all the protease inhibitors that are taken with Norvir can be expected to work well at reducing the viral load, cause some increase in triglycerides and lead to nausea or diarrhea in about 10-15% of people. Most patients should be treated with Norvir boosted protease inhibitors. In special circumstances Reyataz or Lexiva are appropriate without Norvir. There is almost no reason to use Crixivan or Viracept any longer.

DW