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Sep 1, 2007

What about this new drug kp-1461 of Koronispharma? What is exactly viral decay acceleration? Can KP-1461 clear or extinguish the hiv from the body? Please answer me in any case.

Response from Dr. Pierone

KP-1461 is a viral mutagen (formerly tagged as a stealth nucleoside) that induces mutations throughout the viral genome. Test tube studies have shown that HIV is irreversibly extinguished following exposure (via serial passages) to KP-1461. KP-1461 is a pro-drug and is converted in the body to KP-1212, which is the active agent. This drug is incorporated by reverse transcriptase and produces base pair mismatches with mutations randomly inserted throughout the genome. By inducing these mutations it presumably reduces viral fitness and accelerates viral decay a remarkably different mechanism of action than currently available antiretrovirals. Clinical studies have begun so we should have an answer as to whether this agent has activity which extends to humans. Stay tuned!

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