Aug 31, 2007
I am a 39yr old white male. Diagnosed AIDS Feb 2006 VL>100,000, CD4 130. Meds started March 2006 Sustiva/Truvada. Eventually VL <40 in October 2006 CD4 then 330. VL <40 since then and CD4 increasing. June 2007 diagnosed Nephrotic syndrome, stopped Truvada replaced with Kivexa. Current numbers VL<40 CD4 469. Started Rampiril to reduce BP. Due to have kidney biopsy in 2 weeks - ultra sound showed no visable problems. OK now for my questions. My renal specialist is convinced its HIV Nephrotic syndrome, my HIV specialist is not - his argument is that why would it occur after the VL was <40 and under control. Is it possible/are you aware of any similar scenarios? My HIV Consultant is convinced it may be an unreported side effect of Truvada along with the other renal problems it can cause. Again are you aware of other cases of Truvada causing this specific problem. And finally they both agree it could also be a auto immune problem - would this be because of my improved immune system or caused by something else. Your views/opinions much appreciated. Thank you
Response from Dr. Pierone
This is a tough call. Your problem with nephrotic syndrome could be related to HIV, the tenofovir component of Truvada, or possibly an immune reconstitution reaction. Tenofovir generally does not produce nephrotic range proteinuria when it caused kidney problems, but it remains a possibility. So stopping Truvada was a prudent action. The kidney biopsy may be useful to help sort things out. If there is evidence of an immune reaction then a course of corticosteroids may be helpful.
Let us know what happens after the biopsy and is a specific diagnosis is established. Best of luck to you!
Get Email Notifications When This Forum Updates or Subscribe With RSS
- Is Fingering Stripper Safe?
- Is White Discharge A Symptom Of HIV?
- Runny Nose Could I Have Acute HIV Infection
- Sex With A Prostitute How Long Does It Take To Test Positive For AIDS
- After Being Exposed To Hpv How Long Does It Take For Signs Of Cervical Cancer To Appear
- Amoxicillin To Treat Vaginal Infections
This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.
Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.