Jul 26, 2007
After a two-year holiday, I recently resumed antivirals due to experiencing a reduced level of general health for several months.
Initially I was pleased with the combination of Norvir, Truvada, and Reyetaz - the drugs were easy to take and I experienced no grim GI side effects - but after 12 days I developed the usual itching red rash over my torso and extremities, as well as jaundiced sclera. The rash rapidly worsened, and my doctor and I agreed I should cease medication until it cleared up. I did and it has.
Reyetaz is known to cause jaundice, but it's not clear which of the three meds is most likely to have caused the rash. I'll be starting a new regimen shortly, and since I was otherwise pleased with the meds, would prefer not to swap _all_ of them for alternatives. Care to venture an opinion?
Response from Dr. Pierone
Hello, and thanks for posting.
There is no way to really know which of the agents caused this rash but it would be advantageous to be able to continue the Truvada as the nuke backbone if possible. So going with Novir and Lexiva or Kaletra (Norvir and lopinavir) along with Truvada makes sense and you should find out fairly soon if the rash returns. If the rash comes back then this points the finger to Truvada (although Norvir would not be completely in the clear).
Best of luck and let us know how things turn out.
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