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Split Epzicom in Half?
Jul 9, 2007

Hello, Im a 52 year old mom positive since 1988.

The past 5 years Ive taken Trizivir and Viramune. I changed to Epzicom and Viramune 28 days ago. My hope was to reduce the severe fatigue I suffered while on Trizivir and Viramune by taking AZT out of the med mix. Sadly, this does not seem to be the case. I have the same fatigue with odd sweats that occur day or night. My menopause symptoms have thus far been controlled by a Vivelle dot 0.05 mg, so Im reluctant to attribute sweats to menopause.

From GSK, I cant find an answer to the question, which is: Can I cut Epzicom in half and take it with Viramune twice a day? Will the extent of absorption be affected by splitting the tablet in two? From the info below, it seems reasonable to think I cant tolerate the higher dose of Ziagen.

quote from GSK: Patients receiving ZIAGEN 600 mg once daily, experienced a significantly higher incidence of severe drug hypersensitivity reactions and severe diarrhea compared to patients who received ZIAGEN 300 mg twice daily. 5% of patients receiving ZIAGEN 600 mg once daily had severe drug hypersensitivity reactions compared to 2% of patients receiving ZIAGEN 300 mg twice daily. 2% of patients receiving ZIAGEN 600 mg once daily had severe diarrhea while none of the patients receiving ZIAGEN 300 mg twice daily had this event.

Thanks for all your great work!

Response from Dr. Wohl

I would not cut the Epzicom pill in half. There can be variablity in the dose in each half that can potentially cause trouble.

If you want a symmetrical twice a day regimen you could take Ziagen 300 mg, Epivir 150 mg and Viramune 200 mg each twice daily. That would be three pills twice a day.

I would have the sweats checked out by your HIV doc. A repeat viral load should be drawn about now as you have been off of AZT for about a month.

DW



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