|Split Epzicom in Half?
Jul 9, 2007
Hello, Im a 52 year old mom positive since 1988.
The past 5 years Ive taken Trizivir and Viramune. I changed to Epzicom and Viramune 28 days ago. My hope was to reduce the severe fatigue I suffered while on Trizivir and Viramune by taking AZT out of the med mix. Sadly, this does not seem to be the case. I have the same fatigue with odd sweats that occur day or night. My menopause symptoms have thus far been controlled by a Vivelle dot 0.05 mg, so Im reluctant to attribute sweats to menopause.
From GSK, I cant find an answer to the question, which is: Can I cut Epzicom in half and take it with Viramune twice a day? Will the extent of absorption be affected by splitting the tablet in two? From the info below, it seems reasonable to think I cant tolerate the higher dose of Ziagen.
quote from GSK: Patients receiving ZIAGEN 600 mg once daily, experienced a significantly higher incidence of severe drug hypersensitivity reactions and severe diarrhea compared to patients who received ZIAGEN 300 mg twice daily. 5% of patients receiving ZIAGEN 600 mg once daily had severe drug hypersensitivity reactions compared to 2% of patients receiving ZIAGEN 300 mg twice daily. 2% of patients receiving ZIAGEN 600 mg once daily had severe diarrhea while none of the patients receiving ZIAGEN 300 mg twice daily had this event.
Thanks for all your great work!
| Response from Dr. Wohl
I would not cut the Epzicom pill in half. There can be variablity in the dose in each half that can potentially cause trouble.
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