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CD4 plateau?

Jul 9, 2007

I was diagnosed in April 2005 after discovering KS lesions. My CD4 was 78, 5.6% and VL of 65,000, so I suspect I had been positive for some time. I immediately began a regimine of Kaletra and Epzicom. I am now at CD4 of 313, 21% and undetectable VL. I feel like I have "leveled off" at these numbers. Except for 2 missed doses of Kaletra in the first two months of treatment, I have adhered to my regimine without fail. Is there a possiblity that my numbers will continue to improve, or is this all I can expect? Would a change in meds make a difference? (I tolerate this combination very well, with little side effects). I would like to see my CD4 get over 500, but I also don't want to risk moving in the other direction or get increased side effects with a change in meds.

Response from Dr. Pierone

Hello and thanks for posting.

It has been just over two years and your CD4+ lymphocyte count has increased by over 200 cells. You are right on track with regard to immune reconstitution. Although the pace of CD4+ lymphocyte count recovery will likely slow down in the coming years, they should continue to mount. There is no reason to think that the CD4+ lymphocyte count will not rise above 500 cells in the coming years. Best of luck to you!

AZT and lipoatrophy
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