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AIDS Clinical Trials Group (ACTG) reference
May 30, 2007

Dr Young, recently you stated:

<i>"Recent data from the AIDS Clinical Trials Group (ACTG) showed that regimens that contain efavirenz, though simple and generally well tolerated, actually appear to INCREASE risk of liipodystrophy, not decrease. Indeed, in the same study, a boosted protease inhibitor regimen (lopinavir/ritonavir; Kaletra) was shown to cause less lipo when partnered with any nucleoside combination."</i>

Can you provide a link or some other reference to this study? I went to the ACTG websites, and could not find any documentation on these studies.

THANKS SO MUCH!

Response from Dr. Young

Thanks for your post.

I was remiss in not referencing this important study. Here's one reference to ACTG 5142.

Hope this helps. BY



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