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Viramune to Atripla switch

May 21, 2007

Hello, after almost 10yrs on Combivir/Viramune looking to switch to Atripla. Have remained undetectable with no side effects just looking to go to 1 pill/day. Physician and I are trying to determine best transition with least likely development of resistance. Currently thinking OK to drop viramune same day start atripla but keep should keep taking combivir 2 more days. Please advise how you would make this switch? thx.

Response from Dr. Young

Thanks for your post.

The decision to switch shouldn't be done lightly- in your case, you've done very well for years and it seems as if the only reason to switch is to reduce the dosing frequency and pill count (not anything to trivialize). The proposed switch should be fine, provided that your viral load is undetectable.

The simple switch, droping the Combivir/Viramune and starting Atripla on the same day (in the evening) should suffice. Your drug levels should very quickly reach sufficient levels; there's no obvious reason to me why you'd need to continue Combivir any longer than the Viramune.

Hope this helps. Let us know how this turns out for you. BY


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