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PEP Queation

May 11, 2007

What is the current preferred HAART regimen for PEP after a possible exposure and how long should one take the HAART for PEP??

Response from Dr. Wohl

The most recent CDC guidelines on post exposure prophylaxis following occupational expsoure at found at:

These guidelines suggest that 2 drug therapy is okay for less severe exposures with 3 drug therapy indicated for more substantial exposures. I disagree and feel that if therapy is deemed justified by the extent of the risk of HIV transmission involved, then full treatment with at least 3 medications is required.

For info on non-occupational exposures go to:

In both cases prophylaxis should continue for no more than 4 weeks.


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