change of regimen from Videx and Zerit
Apr 29, 2007
thanks doctor for your advice about my son . i will try to talk to the doctor to see if VIDEX can be changed. i am not sure why he chose it maybe because my son s CD4 was 8. now to today s question- from your reply i can pick that ZERIT and VIDEX is not a good combination and its not my first time to hear this. Presently I am on STOCRIN, VIDEX and ZERIT. I have never checked my viral load but my CD4 has always been around 450 so my question is if i were to remove VIDEX and ZERIT what do u suggest i take and in my case is it advisable to change them? your early reply will be welcome so that I can change by monthend. thanx for your help and i wish i had known about your website longtime ago.thanx in advance.
Response from Dr. Pierone
Strocrin is another name for Sustiva and this is a commonly used NNRTI anchor drug. Atripla is the combination of Sustiva, Emtriva, and Viread and has the best side effect profile currently available NNRTI-based regimens.
Zerit and Videx are not commonly used in combination because of additive mitochondrial toxicity. If you live in a country where Viread and Emtriva (or Truvada or Atripla) are available, then this would be the safest combination. If not, then switching either Videx or Zerit for Epivir would be another option which would lower the chance of medication-related side effects.
Let us know how things turn out and best of luck!
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