low level resistance
Mar 28, 2007
1.Can a norvir/atanazavir/truvada regimen be successful in a treatment naive patient if there are mutations that cause low level resistance to Viread?
Response from Dr. Young
Thanks for your post.
1) Yes, the regimen can be successful, but I have to wonder why one would select a tenofovir (Viread, part of Truvada)-based regimen in the presence of resistance. I'd look to other, fully potent nuke options if these were viable options-- the DHHS and IAS treatment guidelines point to the use of AZT/3TC (Combivir) or abacavir/3TC (Epzicom, Kivexa) as other options.
2) Yes, if there's significant resistance to nukes and non-nukes, there are treatment possibilities- definitely a regimen that included a ritonavir (Norvir)-boosted protease inhibitor, perhaps with a recycled nuke, T20 (Fuzeon) or one of the newer investigational drugs, such as maraviroc or raltegravir.
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