Mar 16, 2007
Dear Dr. Wohl,
HIV infection is going unbelievable fast in my life. I am sure that I was infected in July'03, as it was the only risk exposition that I had (a condom broke at the wrong moment :_-( . I started on efv+azt+3tc almost two years after since my viral load was around 80000 and my cd4 droping down to 200. I was undectable up to Dec06, when HIV rebound and my viral reached 580 (cd4 330). I retested my vl in Mar'07 and now it is 4200 (cd4 360, 27 %). I am really very scared about how fast my first regiment failed. I have never forgotten any pill and I took all of them at the time. Now my doctor asked for me a genotype exam, however, it will take around 3 months for getting the results (I am in Brazil). I am really desperate! Everything is going too fast... I am still on my meds. Waiting is the better choice? Could you please be so kind and give me an advice? Looking forward to hearing from you! Bob
| Response from Dr. Wohl
The medications that you were taking are very good and since you were taking your medications as directed, I suspect you may have been infected with a virus that was resistant to one or more of these drugs.
If you can switch to another combination - such as tenofovir + 3TC (or FTC) + Kaletra or other ritonavir boosted protease inhibitor, I would. You risk developing further drug resistance if you stay on your failing regimen.
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