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Dec 11, 2006

hello i was detected in April 2003 with virus load 600.000 and cd4 150. My first therapy was Kaletra, zerit , epivir. In February 2006 i had virus load undetecatble and cd4 950 ! ( about 3 years therapy ). In February 2006 my doctor changed my therapy from kaletra,zerit, epivir to telzir,norvir, truvada. After this change of therapy i still have undetectable virus load but my cd4 are now 500. Why my doctor chandged my therapy ? What to do if cd4 will be 400 after a month ( or 300 or 200 ) ?? What about to return to my firts therapy with kaletra,zerit, epivir ?

Response from Dr. Wohl

I am usure what motivated your doctor to make this change. Certainly, I agree with the discontinuation of the Zerit. This a relatively toxic medication that causes fat wasting, neuropathy and elevations of lipids. Truvada can nicely replace teh Zerit and Epivir and it is one pill once a day.

Why switch the Kaletra for Telzir (fos-amprenavir) + Norvir? That I do not know. These drugs have been found to be very similar. It may be your doctor thought the Telzir was better as far as lipids (now known not to be true).

Why don't you ask her/him?

Your CD4 cell count may just be fluctuating a bit as it can do. I would not worry unless there is a clear decline in your counts.


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