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tenofovir vs abacavir

Nov 10, 2006

I am have been diagnosed hiv for the last 7 years and have enjoyed good health for most of it. I recently changed drs due to a move and he has shown concern regarding the creatin levels now showing in my kidney results and is suggesting i change from tenfovir to abacavir. He advises that I am unlikely to have a reaction to abacavir as he has checked for the indiciator (which i apparently dont have) Mt question is more about what is the level of decease in kidney failure and could this be a blimp. If I continue on tenofovir what sort of damage would i expect and would it be reversed if I switched after monitoring. It seems that because their is an increase my dr immediately wants to change whereas i cant find information as to what happens if i dont. Hope you can help. Thanks

Response from Dr. Wohl

It is hard to answer your question without more information about the tests that have been done. If your blood creatinine has increased, I would need to know what it was and what it has risen to. There are also a couple of formulas that can be used to estimate how well your kidneys are functioning. If the results of one or both of these before and now are available, that would help too. Also, what other medications are you taking and other medical conditions you have.

If your creatinine has consistently increased by half a mg/dL or so from where it was while on tenofovir, and no other casues for this rise is found, I would consider a switch from tenofovir. Some people with a change in kidney function on tenofovir also can have a tell tale drop in their blood phosphorus level.

No one knows what happens if you continue on tenofovir if it is causing a kidney problem. This side effect of tenofovir seems to be pretty rare. But, for most all medications that can cause such problems, it is recommended to stop the drug to prevent further damage.


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