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Is NNRTI class a MUST?

Oct 26, 2006

Is it possible to have combinations of only NRTI + PI instead of NRTI + NNRTI + PI?

I could not tolerate all the NNRTI pills, Rescriptor/delavirdine, Sustiva/efavirenz and Viramune/nevirapine.


Response from Dr. Wohl

Absolutely. There are no data showing any advantage of a regimen of all three classes versus the standard 2 NRTIs+PI or 2 NRTIs+NNTRI.

Triple class therapy only offers more toxicity.

See the current US Department of Public Health Guidelines at You do not have to be a doctor to understand table 6a of these recommendations. You will see that there are quite a few PI based regimens that are used and effective.


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