sti and resistance
Apr 5, 2001
i have read alot recently about studies taking meds every other week . 1 wk on 1 wk off. I discussed this with my doc and he does not reccomend trying it. Can resistance occur if i were to concider trying it? current meds 3tc, d4t, ziagen. Vl <50 cd4 700. Vl at starting meds was 15000 aprx 5 yrs ago. lowest tcells were 279. also why does resistance occur if you miss a few doses and resistance doesnt occur if you stop for a period of a few months and go back on?
Response from Dr. Boyle
There is currently a trial underway at the NIH to evaluate this strategy called "Stuctured Intermittent Therapy". To this date, they have not reported the development of resistance, but this is still not something that should be done outside of a very carefully monitored setting. If things go seriously awry, you could end up with many NRTI mutations that could significantly compromise your chances for future treatment. So, like your doctor, I would not advise you to try this strategy yet. Regarding your second question, resitance generally does not develop when you are off antiretrovirals because there is no "drug pressure" to encourage resistant quasispecies to persist and replicate. Missing doses or whenever you are starting or stopping medications is a particularly dangerous time since as drug levels drop the virus may start to replicate and there may be just enough of one or more of the drugs around to supply the requisite "drug pressure" for resistance to develop and persist. This may be especially true regarding 3TC, which requires just one mutation (M184V) for high-grade resistance to develop. BB
Get Email Notifications When This Forum Updates or Subscribe With RSS
- Tingling Lips After Anal Sex Top Sign Of HIV AIDS
- Vaginal Discharge After Fisting Worried I Have HIV
- White Spots After Unprotected Vaginal Sex Worried I Have HIV
- Can You Get Std If You And Your Partner Are Virgin And Have Oral Sex?
- Does Amoxicillin Cure Stds?
- How Long Does The Hpv Vaccine Last?
This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.
Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.