|treatment and CD4 %
Sep 6, 2006
I have been looking through published treatment guidelines and have been unable to find recommendations for starting treatment based on CD4% (as opposed to absolute CD4 count). I am curious about when treatment would be recommended based on a low CD4% with a normal CD4 count.
Thanks in advance for your response!
| Response from Dr. Young
Thanks for your post.
You're correct insomuch as most treatment guidelines don't address the question about CD4 percentages and when to start medications. For reference, here's a link to the most recent (August 2006) IAS-USA guidelines.
If one makes the generalized assumption that on average, each absolute CD4 count of 100 is equivalent to a ~7.5 percentage points, then the typical person with an absolute count of 350 should have a CD4% of about 25-26.
In practical terms, I usually suggest that patients with absolute counts below 350 or percentages below 25 consider treatment. When counts are below 200 or 15%, then HAART should definitely be started (if possible).
I hope this helps. BY
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