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Med change from NNRTI to PI?
Sep 3, 2006

My husband has a very low cd count of 8 and also hep C and hep b, along with depression which is causing adherence problems, currently on combivir and sustiva, twice daily, he's missed doses quite a few times. How long does it take to develop resistance, {also he went off his meds a few months, then went back on them} the same meds. His cd count never has got very high it went up to 38, then back to 8. If we ask for a change in meds what would be easier to take, morning preferably, once daily and good with raising low cd counts?

Response from Dr. Pierone

Viral resistance may develop quickly with a NNRTI-based regimen when adherence is spotty. On this basis alone a once daily PI-based regimen might make more sense for your husband. An example would be Truvada, Norvir, and Reyataz. It bears mentioning that proactive treatment of his depression will go a long way towards improving his adherence to HIV medications. Best of luck!


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