reservoir in gut?
Jul 30, 2006
Hi there, just read an article on the BBC news website: Californian group showed the human gut is a reservoir. Though HAART may elevate CD4, cause drop in virusload in blood, it has less effect on HIV in the gut (i imagine they mean the human epithelian cells in the gut, not the faecal mass in there). They state that the hit hard hit early method of HAART may be better than waiting for a few years until CD4 drops/VL increases, as the damage to the gut and the extent of HIV presence in the gut is less pronounced when starting right after/during seroconversion. Any thoughts?
Response from Dr. Wohl
It is now well appreciated that there are many places in the body that can serve as 'reservoirs' for HIV. Gut associated lymphoid tissue (GALT) is one such compartment. GALT is rich in immune cells that work to protect us from the things we ingest. GALT is in the wall of our intestines and like lymph nodes can harbor CD4 and other cells that are infected with the virus. These cells are infected as HIV travels through teh blood and lymph system.
The presence of these reservoirs of virus has prompted some to call for early HIV therapy in an attempt to limit the size of these infected pools of cells. Others caution that these reservoirs may be established very early in infection and that unless treatment is started within days to weeks of infection there may be little effect of therapy on the establishment or extent of GALT and other infected compartments.
Get Email Notifications When This Forum Updates or Subscribe With RSS
- Sex With A Prostitute And Possible HIV Exposure
- Black Spots After Open Mouth Kissing Worried I Have HIV
- Coated Tongue After Licking Vagina Worried I Have HIV
- Flu Symptoms After Unprotected Oral Sex Without Ejaculation Worried I Have HIV
- Itchy Scrotum After Licking Penis Sign Of HIV AIDS
- Painful Red Spots After Oral Sex Worried I Have HIV
This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.
Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.