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integrase inhibitor
Jun 21, 2006

i know that integrase inhibitor are doing very very well..the results are very impressive given the higly drug resistant popolation studied.

I realize that the new integrase drugs reduced the viremia because there are less cell infect ( the virus needs the cell to moltiplicate itself).... not because the drugs block the assembling of the new virus ... m i correct?... i f i m correct.. the reduction of cell. can be extended to any kind of reservoirs? is there any hope that this new class of drug can permit the eradication of hiv?.

Response from Dr. Young

Thanks for your post.

Integrase inhibitors prevent the incorporation (or integration) of the HIV chromosome into the human (CD4 cell) chromosome. There are several integrase inhibitors in various stages of development. By doing so, it's theoretically possible that the size of the pool of infected cells might decrease (including reservoirs).

Eradication is a long way off and highly, highly speculative, but this would be an important step in preventing the establishment of new sanctuaries or reservoirs of HIV. BY

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