I have a cd4 of about 280-310, with slightly detectable viral load. I have been on Epivir 300mg, Viracept 625mg, Videx EC, Ziagen for about five years. I did not tolerate Crixivan(liver problems), or Norvir(diarrhea. I have gone through AZT, ddc, d4t, am over 20 years into this thing, and took 5 years to get from 24 t-cells to over 200. My anti-retroviral therapy started in 1995. I take my meds almost without fail. It would be nice to have fewer pills(and less expensive: I work full time and have insurance), but I don't want to upset the apple cart. What do you think?

Thank you for your post.

If I'm correct in the assumption that you've only stopped medications (Crixivan and Norvir) for side effects and haven't had any suspicion of drug resistance, then it would be quite possible to simplify your drug regimen.

At the very least, it would be easy to change from 3TC + abacavir to the fixed dose combination abacavir/3TC (Epzicom). It's also possible to make other, more sweeping changes, such as reduction to two NRTIs or change from nelfiinavir to other "3rd" drugs, but I'd hesitate to make specific recommendations without details.

I hope this helps. BY