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High dose Kaletra revisited

Jun 3, 2006

What would be the clinical reason for taking Kaletra 1200mg/300mg BID? Isn't this awfully high?

Response from Dr. Pierone

Yes, this is a high dose and would typically be recommended when attempting to overcome partial resistance to Kaletra by increasing the dose in order to achieve higher drug concentrations. Another scenario is when double boosting of PIs is being utilized for known drug-resistant virus and the PIs have a drug interaction that lower Kaletra levels (Tipranavir would be an example of this). These are the 2 scenarios where I think a higher than standard dose might be selected. Ask your clinician and see what he or she is using as a rationale for the higher dose. Thanks for posting.

drug combo for salvage after Combivir
Meds soon?

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