reyetaz viread combo
May 25, 2006
My partner has been prescribed Reyetaz 400 and Viread in a once daily dose. Everything I have read so far indicates that if these 2 drugs are to be combined, Reyetaz should be reduced to 300 and Ritonivir 100 added to the mix. My partner is not exactly treatment naive, he has tried a few combos but didn't stick with them for more than a month and has not taken anything for over 6 years. His t-cells are in the 500 range and viral load, although usually hovering in the 35,000 range consistently for the past few years, is presently down to 8000. Is this combo advisable? I also recall reading that Reyetaz and Viread taken together can speed resistance to both. He has not begun this regimen yet and we don't want to approach our Doctor about this until we have the right information.
Response from Dr. Young
Thanks for your post.
You are absolutely correct-- tenofovir (Viread, TDF) significantly lowers the exposure to atazanavir (Reyataz). For this reason, if the two drugs are coadministerd, ritonavir (Norvir) must be used to compensate for the reduction.
I'd be really reluctant to use the two without ritonavir, since as you suggest, the lower atazanavir levels really jeoopardize the potency of the regimen and increase the likelihood that resistance (an irreversible complication) can occur.
If your (his) doctor isn't aware of this interaction, I'd be certain to raise the issue-- multiple guidelines and the FDA-approved package insert make these points.
I hope this helps. BY
Get Email Notifications When This Forum Updates or Subscribe With RSS
- Does Blood In Urine Mean I Have AIDS?
- Is Itchy Skin A Symptom Of Acute HIV Infection?
- Loose Stool Could I Have Acute HIV Infection
- Can AIDS Be Transmitted Through Blowjob From A Prostitute?
- Coated Tongue After Licking Vagina Worried I Have HIV
- Cold Feet After Erotic Massage Worried I Have HIV
This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.
Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.