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Tenefovir, Emtriva and Fosamprenavir for wild type virus

Apr 9, 2006

Would Teneforvir, Emtriva and Fosamprenavir(not boosted with Retonavir) be a potent combo for myself who is found to carry wild type virus? The present regimen includes Kaletra and Retonavir which is giving me endless GI problems. I am hyper-sensitive to quite a few of the old HIV meds.So always looking for a better cocktail. cheers :)


Response from Dr. Young

Thanks for your post.

Though not (yet) formally tested, the combination of tenofovir (Viread), FTC (Emtriva; also available in combination with tenofovir as Truvada) with unboosted fosamprenavir (Lexiva, Telzir) should be quite well tolerated.

A stable switch from tenofovir, FTC and Kaletra should be very safe, provided that your viral load is controlled.

It's been our experience that even ritonavir (Norvir)-boosted fosamprenavir is very well tolerated; the unboosted strategy should probably be even better tolerated.

Just in case you (or our readers) were wondering unboosted atazanavir (Reyataz) should not be used with tenofovir, because tenofovir lowers the levels of atazanavir. Tenofovir + atazanavir combinations should include ritonavir.

Cheers back at you, BY

Andrew Stimpson

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