The Body: The Complete HIV/AIDS Resource
Follow Us Follow Us on Facebook Follow Us on Twitter Download Our App 
Professionals >> Visit The Body PROThe Body en Espanol
Ask the Experts About

Choosing Your MedsChoosing Your Meds
Rollover images to visit our other forums!
  • Email Email
  • Glossary Glossary

ZFN and making stem cells immune
Feb 2, 2006

Hi Dr. Perione,

I came across two very interesting immune based approaches. One group is genetically altering blood stem cells, so all their progeny will be resistant to HIV.


Another group is using Zinc Finger Nucleases (a new, precise way of silencing genes) to knock out the CCR5 gene in T cells. (

I think both of these sound quite promising, but what I think is even more exciting is if these two groups would join forces. Have you heard of this work, and what do you think?

Thanks, George

Response from Dr. Pierone

Hello and thanks for sharing the stem cell link and the Zinc finger link . These research endeavors are 2 examples of the types of innovative approaches that are being attempted in order to gain control of HIV replication without the need for lifelong HAART.

These stem cell and gene therapeutic sciences are in their infancy, so it seems unlikely that these first attempts will result in a major breakthrough, but one never knows until the attempt is made. It is certainly long past time for bold action in the HIV research arena and trials like this are most welcome.

Thanks again for sharing these reports with our readers.

Slow release meds
Change in complexion.

  • Email Email
  • Glossary Glossary



This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.

Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.

Review our complete terms of use and copyright notice.

Powered by ExpertViewpoint