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Virus type

Jan 24, 2006

Hi. Just wondered if you could explain the difference please between "mixed virus and dual-tropic virus. Thanks and all the best. S

Response from Dr. Young

Dear S,

This topic refers to what HIV co-receptor(s) the virus uses to enter CD4 cells. There are two HIV coreceptors, called CCR5 ("R5") and CXCR4 ("X4"). A mixed virus means that there is a mixed population of viruses, some that use exclusively R5 and others that use exclusively X4. A dual-tropic virus refers to viruses that can use either R5 or X4 to enter. BY

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