Jan 11, 2006
I am in type of medication Lamivudine stavudine + sustiva, because I am Italian I asch some question to one Italian doctor and she said the type of medication on long term I can become tossic you agree? please what will be you opinion on this type of medication I been to Thailand and one doctor said this type of medication is very good, I am confuse at the moment thank and Happy New Year Tom
Response from Dr. Young
Tom- Happy New Year to you and thank you for your post. Your question really is one of the different treatment approaches in different countries.
The drug at issue is your stavudine (d4T, Zerit)-- while d4T is commonly used in the developing world like Thailand and Africa (and is generally well tolerated in the short term), it is associated with a higher rate of certain types of toxicity than other drugs in the nucleoside class. Cases of lipoatrophy (loss of body fat), pancreatitis and peripheral neuropathy are particularly associated with d4T.
Because of this, in places of the world where other options exist, d4T is typically relegated to a last-option drug. In our practice, first-line use of d4T has been replaced with tenofovir (Viread/Truvdad), abacavir (Ziagen/Epzicom) or even the old standard- AZT.
I hope this helps sort out the confusion. BY
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