New Medications before 2011
Jan 9, 2006
Dear Dr. Pierone: Thank you for your advice on when to start medications. I have not reached the starting point yet but I will talk to my doctor to see if its possible to start before my cd4 count drops to 350. I have been doing a lot of "research" on the internet and some authors think that the number of medications available by 2011 will be doubled. Maybe 20 or more new drugs will be on the market. Is there anything that can be considered a revolution or a completely different new approach to treat HIV infection? A cure still seems impossible, but...When will there be a resistance-proof drug against HIV? Thank you in advance for your answer. I am very interested in having your opinion. John. (Madrid-Spain)
Response from Dr. Pierone
Revolutionary advances are few and far between, but incremental progress is assured. There are many new exciting agents in the pipeline for treatment of HIV infection. These include CCR-5 inhibitors, integrase inhibitors, maturation inhibitors, and attachment inhibitors. None of these agents would be expected to be resistance proof based on what we know about mechanisms of development of viral resistance, but time will tell.
My personal view is that the great step forward in HIV therapeutics will not simply be developing a less resistance prone drug with fewer side effects. Instead, I believe the transformational technologies may turn out to be based on gene therapy or immune-based approaches. Stay tuned!
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