The Body: The Complete HIV/AIDS Resource
Follow Us Follow Us on Facebook Follow Us on Twitter Download Our App 
Professionals >> Visit The Body PROThe Body en Espanol
Ask the Experts About

Choosing Your MedsChoosing Your Meds
Rollover images to visit our other forums!
Recent AnswersAsk a Question
  • Email Email
  • Glossary Glossary

Entry Inhibitors/Future

Jan 9, 2006

Dr. Wohl, First off, happy new year. I hope that 2006 brings some exciting developments in the treament of HIV. Hopefully something that is very difficult to get gain resistant to and is easy on the body. That said, do these entry inhibitors really have a chance? I am beginning to think that class of therapy isn't the "answer". If so, what REALISTICLY, not gene therapy, will be the next new thing? Please give me something to look forward to in 2006.

Response from Dr. Wohl

Happy New Year to you.

2006 may be a little shy of revolutionary new therapies (sorry). It IS likely we will see a new protease inhibitor (TMC114) which looks like it will be helpful for people with resistant virus.

What we really can use is a second generation NNRTI (family of drugs that includes Sustiva and Viramune). When a person gets resistance to one of these they usually are resistant to all three of the drugs in this class. As Sustiva is a common first line drug, those who experience resistance to this drug are left to protease inhibitors. An NNRTI that could salvage Sustiva and Viramune failure would be wonderful and is something we may see in 2007.

Don't forget integrase inhibitors. Merck has one that is clinical trials.


men/women ratio

  • Email Email
  • Glossary Glossary

 Get Email Notifications When This Forum Updates or Subscribe With RSS



This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.

Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.

Review our complete terms of use and copyright notice.

Powered by ExpertViewpoint