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Kaletra once a day
Jan 4, 2006

Hi, I just had a really bad experience with sustiva, after going from one symptom to another me and my doctor decided to switch to something else. He is suggesting rayataz, but I feel more confortable with kaletra as I know people taking it for a good time with no major side effects. I've been on combivir for six months in year 2000 and six months combivir + viracept on 2003 (pregnancies) and only now have a CD4 of 208 and started sustiva + truvada two weeks ago (just stopped yesterday night). Do you think it's safe to do kaletra (4 pills once a day) + truvada?

Response from Dr. Young

Thanks for your post.

Sorry to hear about your Sustiva tribulations. A switch to lopinavir/ritonavir (Kaletra) tablets (4 per day) should be fine-- certainly well studied with Truvada (there's no current clinical trials data for atazanavir (Reyataz) with tenofovir/FTC (Truvada)). Once-daily dosing may cause slightly higher rates of diarrhea than twice-daily lopinavir/ritonavir. But, since you tolerated 6 months of nelfinavir (Viracept), you shouldn't have any significant risk of intolerance.

Be well, BY



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