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First meds/fosamprenavir
Dec 24, 2005

What are the 3 most commonly prescribed combinations of first meds now? What drugs go with fosamprenavir? Is fosamprenavir a drug that could be used for a person's first drug treatment?

Response from Dr. Young

Thanks for your post.

If one follows US treatment guidelines, the most highly recommended regimens are AZT/3TC (Combivir) or tenofovir/FTC (Truvada) with either efavirenz (Sustiva, Stocrin) or lopinavir/ritonavir (Kaletra).

Because treatment guidelines often lag behind practice habits, it's important to know that among the nukes, all of the fixed-dose combinations, Combivir, Truvada and abacavir/3TC (Epzicom) are most frequently used, with a nod to the once-daily Truvada and Epzicom in terms of recently initiated combos. Among the PIs, Kaletra's use had declined in recent months in favor of the use of once-daily combos with either atazanavir (Reyataz) or ritonavir-boosted fosamprenavir (Lexiva). The availability of the new tablet formuation of Kaletra will offer yet another lower pill count, once-daily PI option.

We've used fosamprenavir with success for several years-- among treatment-naive patients, the drug has been extensively studied with abacavir and 3TC; studies with other nukes are ongoing. We've used once-daily ritonavir boosted fosamprenavir primarily with Epzicom and Truvada for first-line treatment with excellent results; patients rarely report any significant side effects. The option of once-daily treatment without dietary restriction and minimal impact on lipids (cholesterol) have been attractive to many patients.

I hope this helps, good health to you. BY



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