The Body: The Complete HIV/AIDS Resource
Follow Us Follow Us on Facebook Follow Us on Twitter Download Our App 
Professionals >> Visit The Body PROThe Body en Espanol
Ask the Experts About

Choosing Your MedsChoosing Your Meds
Rollover images to visit our other forums!
Recent AnswersAsk a Question
  • Email Email
  • Glossary Glossary

Request for ACTG Study Proposal

Dec 1, 2005

Dear Dr. Pierone, Recent reports from from Immunitor USA Inc., College Park, MD 20740, USA, the Human Biology Research Center (HBRC), Hadassah University Hospital, Ein-Kerem, Jerusalem, Israel, eFaculte de Medecine Broussais-Hotel Dieu-EHESS, 54 Blvd Raspail, 75006 Paris, France, and others, found that HIV+ patients often have T cell autoimmunity. Small pilot studies have confirmed this, by use of a vaccine that induces immune tollerance of T cells. Could you, or one of your ACTG colleagues please write a proposal for a similar study?

Is the concept of inducing tolerance patented?

How expensive might the preparation of such a vaccine be? And would the vaccine need to be patient specific?

Regards, Tom


Response from Dr. Pierone

Hello and thanks for posting. The references regarding immune tolerance are very interesting and it sounds like the investigators are pursuing some of these leads. I don¡t think that the notion of inducing tolerance can be patented since immune-based therapy based on this principle have been used for decades in allergy desensitization

Not to throw cold water on your request, but generally an investigator needs to get really excited about a particular research project in order to put in the enormous effort to write a research protocol and attempt to get funding.

Speaking of funding, I am not affiliated with the ACTG (which is mainly an academic oriented collaboration) and don¡t have influence with this organization. However, the National Institute of Health (NIH) provides funding through the NAIAD and is attempting to re-organize the AIDS research infrastructure. We will see how successful this effort is in the spring of 2006 when the new grants are awarded. We will see if some young, dynamic, and innovative groups are allowed entry (like ours ) or if the same old crew continue to do very expensive, boring, and predictable studies several years after they are clinically relevant. Stay tuned!

change from working regimen????????
lots of questions - had to get them asked...

  • Email Email
  • Glossary Glossary

 Get Email Notifications When This Forum Updates or Subscribe With RSS



This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.

Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.

Review our complete terms of use and copyright notice.

Powered by ExpertViewpoint