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The finish of CCR5 WAY?
Nov 12, 2005

Dear Gerald

One more time your friend from Buenos Aires...with my terrorific english !!!!

Today i wrote with sad spirit one notice in the newspaper about GSK...abandoned his experiment with de CCR5 correceptor....of course I know this is "normal" or usual" in scientific experiments...but as you know a lot of positive people will have put "coins" in this new drugs.

Is this the final of this new type of drougs? What is your personal opinion? what about Shering Plough in relationship with the ccr5 experiment????

Gracias amigo por tu tiempo.

Un abrazo desde la primavera de Buenos Aires.

Response from Dr. Pierone

Although GSK pulled the plug on its CCR5 inhibitor there is still much excitement and active research into this class of agents. Pfizer and Shering both have agents under study. One of the worries about this drug class is that it may lead to pressure on the virus to evolve towards the CXCR4 phenotype, which tends to be more virulent. All we can really say at this point is that studies currently under way should provide answers in the not too distant future. Thanks for posting and stay tuned!

Aunque GSK tiró del enchufe en su inhibidor CCR5 todavía hay muchoentusiasmo y activo investigue sobre esta clase de agentes. Pfizer y Shering ambos tienen agentes bajo estudio. Uno de se preocupa de esta clase de la droga es que puede conducir ala presión en el virus de desarrollarse hacia el phenotype CXCR4, cuál tiende para ser más virulento. . Todo lo que podemos realmente decir a este punto es que los estudiosen curso deben proporcionar actualmente respuestas. ¡Gracias por fijar y la estancia templada! .



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